| Pronunciation |
 (oks
AM ni
kwin) |
 |
| U.S. Brand Names |
| Vansil™ |
|
| Generic Available |
|
No |
|
| Pharmacological Index |
|
Anthelmintic |
|
| Use |
|
Treatment of all stages of Schistosoma mansoni infection |
|
| Pregnancy Risk Factor |
|
C |
|
| Warnings/Precautions |
|
Rare epileptiform convulsions have been observed within the first few hours of administration, especially in patients with a history of CNS pathology |
|
| Adverse Reactions |
|
>10%: Central nervous system: Dizziness, drowsiness, headache <10%: Central nervous system: Insomnia, malaise, hallucinations, behavior changes Gastrointestinal: GI effects, orange/red discoloration of urine Hepatic: Elevated LFTs Dermatologic: Rash, urticaria, pruritus Renal: Proteinuria |
|
| Drug Interactions |
|
May be synergistic with praziquantel |
|
| Mechanism of Action |
|
Not fully elucidated; causes worms to dislodge from their usual site of residence (mesenteric veins to the liver) by paralysis and contraction of musculature and subsequently phagocytized |
|
| Pharmacodynamics/Kinetics |
|
Absorption: Oral: Well absorbed Metabolism: Extensive in the GI tract via oxidation Half-life: 1-2.5 hours Time to peak: 1-3 hours Elimination: <2% unchanged in urine; up to 75% of metabolites excreted in urine |
|
| Usual Dosage |
|
Oral: Adults: 12-15 mg/kg as a single dose |
|
| Dietary Considerations |
|
May be administered with food |
|
| Test Interactions |
|
May interfere with spectrometric or color reaction urinalysis |
|
| Mental Health: Effects on Mental Status |
|
Dizziness and drowsiness are common; may cause insomnia or hallucinations |
|
| Mental Health: Effects on Psychiatric Treatment |
|
None reported |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
Take with food |
|
| Dosage Forms |
|
Capsule: 250 mg |
|
| References |
|
"Drugs for Parasitic Infections," Med Lett Drugs Ther, 1993, 35(911):111-22. |
|
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