Yes: Cream

Antifungal Agent, Topical

Topically in the treatment of tinea pedis, tinea cruris, and skin infections caused by dermatophytic fungi (ringworm)

C

Not effective in the treatment of scalp or nail fungal infections; children <2 years of age, hypersensitivity to any component

May irritate sensitized skin; topical application poses a potential risk of toxicity to infants and children; known to cause serious and irreversible optic atrophy and peripheral neuropathy with muscular weakness, sensory loss, spastic paraparesis, and blindness; use with caution in patients with iodine intolerance

1% to 10%:

Neuromuscular & skeletal: Peripheral neuropathy

Ocular: Optic atrophy

No data reported

Chelates bacterial surface and trace metals needed for bacterial growth

Absorption: With an occlusive dressing, up to 40% of dose can be absorbed systemically during a 12-hour period; absorption is enhanced when applied under diapers

Half-life: 11-14 hours

Elimination: Conjugated and excreted in urine

Children and Adults: Topical: Apply 2-3 times/day; do not use for longer than 7 days

Thyroid function tests (decreased ¹³¹I uptake); false-positive ferric chloride test for phenylketonuria

None reported

May interfere with thyroid function tests

No information available to require special precautions

No effects or complications reported

Cleanse affected area before application; can stain skin and fabrics; for external use only; avoid contact with eyes and mucous membranes

Watch affected area for increased irritation

Cream: 3% (30 g)

Ointment, topical: 3% (30 g)

American Academy of Pediatrics Committee on Drugs, "Clioquinol (Iodochlorhydroxyquin, Vioform®) and Iodoquinol (Diiodohydroxyquin): Blindness and Neuropathy," Pediatrics, 1990, 86(5):797-8.