No

Anticholinergic Agent; Anti-Parkinson's Agent (Anticholinergic)

Adjunct in the therapy of all forms of Parkinsonism; control of extrapyramidal symptoms secondary to antipsychotics

C

Angle-closure glaucoma; GI or GU obstruction; hypersensitivity to biperiden

Use with caution in patients with angle-closure glaucoma, peptic ulcer, urinary tract obstruction, hyperthyroidism; some preparations contain sodium bisulfite; syrup contains alcohol

Cardiovascular: Orthostatic hypotension, bradycardia (I.V.)

Central nervous system: Drowsiness, euphoria, disorientation, agitation

Gastrointestinal: Constipation, xerostomia

Genitourinary: Urinary retention

Ocular: Blurred vision

Decreased effect: May increase gastric degradation of levodopa and decrease the amount of levodopa absorbed by delaying gastric emptying; the opposite may be true for digoxin

Therapeutic effects of cholinergic agents (tacrine, donepezil) and neuroleptics may be antagonized

Increased toxicity: Central and/or peripheral anticholinergic syndrome can occur when administered with amantadine, rimantadine, narcotic analgesics, phenothiazines and other antipsychotics (especially with high anticholinergic activity), tricyclic antidepressants, quinidine and some other antiarrhythmics, and antihistamines

Biperiden is a weak peripheral anticholinergic agent with nicotinolytic activity. The beneficial effects in Parkinson's disease and neuroleptic-induced extrapyramidal reactions are believed to be due to the inhibition of striatal cholinergic receptors.

Serum half-life: 18.4-24.3 hours

Time to peak serum concentration: 1-1.5 hours

Adults:

Extrapyramidal:

Oral: 2 mg 1-3 times/day

I.M., I.V.: 2 mg every 30 minutes up to 4 doses or 8 mg/day

I.V. must be given slowly

No information available to require special precautions

Dry mouth, nose, and throat very prevalent in patients taking this drug

May cause drowsiness

No significant difference in onset of I.M. or I.V. injection, therefore, there is usually no need to use the I.V. route. Improvement is sometimes noticeable a few minutes after injection. Do not discontinue drug abruptly.

Injection, as lactate: 5 mg/mL (1 mL)

Tablet, as hydrochloride: 2 mg