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Calcium | ||
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| Pronunciation |
 (a
TEN oh lole & klor THAL i
done) |
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| U.S. Brand Names |
| Tenoretic® |
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| Generic Available |
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Yes |
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| Synonyms |
| Chlorthalidone and Atenolol |
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| Pharmacological Index |
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Antihypertensive Agent, Combination |
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| Use |
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Treatment of hypertension with a cardioselective beta-blocker and a diuretic |
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| Pregnancy Risk Factor |
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D |
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| Adverse Reactions |
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See individual agents |
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| Usual Dosage |
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Adults: Oral: Initial: One (50) tablet once daily, then individualize dose until optimal dose is achieved |
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| Dietary Considerations |
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Should be administered on empty stomach |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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Noncardioselective beta-blockers (ie, propranolol, nadolol) enhance the pressor response to epinephrine, resulting in hypertension and bradycardia. This has not been reported for atenolol, a cardioselective beta-blocker. Therefore local anesthetic with vasoconstrictor can be safely used in patients medicated with atenolol. Many nonsteroidal anti-inflammatory drugs such as ibuprofen and indomethacin can reduce the hypotensive effect of beta-blockers after 3 or more weeks of therapy with the NSAID. Short-term NSAID use (ie, 3 days) requires no special precautions in patients taking beta-blockers. |
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| Patient Information |
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See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding. |
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| Nursing Implications |
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May contain povidone as inactive ingredient |
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| Dosage Forms |
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Tablet: 100: Atenolol 100 mg and chlorthalidone 25 mg |
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| References |
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Foster CA and Aston SJ, "Propranolol-Epinephrine Interaction: A Potential Disaster," Plast Reconstr Surg, 1983, 72(1):74-8. Wong DG, Spence JD, Lamki L, et al, "Effect of Nonsteroidal Anti-inflammatory Drugs on Control of Hypertension of Beta-Blockers and Diuretics," Lancet, 1986, 1(8488):997-1001. Wynn RL, "Dental Nonsteroidal Anti-inflammatory Drugs and Prostaglandin-Based Drug Interactions-Part Two," Gen Dent, 1992, 40(2):104, 106, 108. Wynn RL, "Epinephrine Interactions With Beta-Blockers," Gen Dent, 1994, 42(1):16, 18. |
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