| Pronunciation |
 (am
SIN oh
nide) |
 |
| U.S. Brand Names |
| Cyclocort® Topical |
|
| Generic Available |
|
No |
|
| Pharmacological Index |
|
Corticosteroid, Topical |
|
| Use |
|
Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses (high potency corticosteroid) |
|
| Pregnancy Risk Factor |
|
C |
|
| Contraindications |
|
Hypersensitivity to amcinonide or any component; use on the face, groin, or axilla |
|
| Warnings/Precautions |
|
Adverse systemic effects may occur when used on large areas of the body, denuded areas, for prolonged periods of time, with an occlusive dressing, and/or in infants or small children; occlusive dressings should not be used in presence of infection or weeping lesions |
|
| Adverse Reactions |
|
1% to 10%: Dermatologic: Itching, maceration of skin, skin atrophy, erythema, dryness, papular rashes Local: Burning, irritation <1%: Hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, striae, miliaria |
|
| Overdosage/Toxicology |
|
Symptoms of overdose include cushingoid appearance (systemic), muscle weakness (systemic), osteoporosis (systemic) all with long-term use only. When consumed in excessive quantities for prolonged periods, systemic hypercorticism and adrenal suppression may occur; in those cases, discontinuation and withdrawal of the corticosteroid should be done judiciously. |
|
| Drug Interactions |
|
No data reported |
|
| Mechanism of Action |
|
Stimulates the synthesis of enzymes needed to decrease inflammation, suppress mitotic activity, and cause vasoconstriction |
|
| Pharmacodynamics/Kinetics |
|
Absorption: Adequate through intact skin; increases with skin inflammation or occlusion Metabolism: In the liver Elimination: By the kidney and in bile |
|
| Usual Dosage |
|
Adults: Topical: Apply in a thin film 2-3 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary. |
|
| Mental Health: Effects on Mental Status |
|
None reported |
|
| Mental Health: Effects on Psychiatric Treatment |
|
None reported |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
Before applying, gently wash area to reduce risk of infection; apply a thin film to cleansed area and rub in gently and thoroughly until medication vanishes; avoid exposure to sunlight, severe sunburn may occur |
|
| Nursing Implications |
|
Assess for worsening of rash or fever |
|
| Dosage Forms |
|
Cream: 0.1% (15 g, 30 g, 60 g) Lotion: 0.1% (20 mL, 60 mL) Ointment, topical: 0.1% (15 g, 30 g, 60 g) |
|
|
|
Copyright © 1978-2000 Lexi-Comp Inc. All Rights Reserved
